Genetic variation in the vaspin gene affects circulating serum vaspin concentrations
نویسندگان
چکیده
منابع مشابه
Serum vaspin concentrations in human obesity and type 2 diabetes.
OBJECTIVE Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabete...
متن کاملInsulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans
It has been hypothesized that insulin might mediate meal-related diurnal variation in vaspin serum concentrations. We therefore investigated whether insulin affects serum vaspin levels in humans. Vaspin serum concentrations were determined by ELISA in 10 healthy individuals, who underwent an insulin tolerance test (ITT) for the evaluation of pituitary ACTH and growth hormone reserve. The ITTs w...
متن کاملSerum vaspin levels in hypothyroid patients.
OBJECTIVE To elucidate the link between TSH and obesity, the relationship between TSH and adipocytokines were previously studied. Animal studies demonstrated a possible relationship between vaspin levels and thyroid functions. In this study, we aimed to investigate vaspin levels in hypothyroid states and its relationship with insulin resistance parameters in humans. DESIGN Prospective observa...
متن کاملSerum vaspin concentrations in relation to insulin sensitivity following RYGB-induced weight loss.
BACKGROUND Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic Roux-en-Y gastric bypass (RYGB) surgery. METHODS Longitudinal, clinical in...
متن کاملCorrelations between serum vaspin and type 2 diabetic retinopathy
This study investigated the role of vaspin in the occurrence and development of type 2 Diabetic Retinopathy (DR). A total of 90 patients clinically diagnosed with type 2 diabetes mellitus (T2DM) were divided into Non-DR (NDR), Non-Proliferation DR (NPDR), and Proliferation DR (PDR) groups, while healthy subjects were included in a control group. Serum Fasting Blood Glucose (FBG), Fasting Insuli...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2012
ISSN: 0307-0565,1476-5497
DOI: 10.1038/ijo.2012.133